High homocysteine, low B12 and low paraoxonase 1 in autism

Posted by: “marlascripter” mscripter@dslextreme.com  

Sun Aug 22, 2010 8:46 am (PDT)

High levels of homocysteine [?] and low serum paraoxonase 1 arylesterase activity in children with autism.

PaÅŸca SP, NemeÅŸ B, Vlase L, Gagyi CE, Dronca E, Miu AC, Dronca M
Faculty of Medicine, Iuliu Haieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Autism is a behaviorally defined disorder of unknown etiology that is thought to be influenced by genetic and environmental factors. High levels of homocysteine [?] and oxidative stress are generally associated with neuropsychiatric disorders. The purpose of this study was to compare the level of homocysteine [?] and other biomarkers in children with autism to corresponding values in age-matched healthy children. We measured total homocysteine (tHcy), vitamin B(12), paraoxonase and arylesterase activities of human paraoxonase 1 (PON1) in plasma and glutathione peroxidase (GPx) activity in erythrocytes from 21 children: 12 with autism (age: 8.29 +/- 2.76 years) and 9 controls (age: 8.33 +/- 1.82 years). We found statistically significant differences in tHcy levels and in arylesterase activity of PON1 in children with autism compared to the control group: 9.83 +/- 2.75 vs. 7.51 +/- 0.93 micromol/L (P < or =0.01) and 72.57 +/- 11.73 vs. 81.83 +/- 7.39 kU/L (P < or =0.005). In the autistic group there was a strong negative correlation between tHcy and GPx activity and the vitamin B(12) level was low or suboptimal. In conclusion, our study shows that in children with autism there are higher levels of tHcy, which is negatively correlated with GPx activity, low PON1 arylesterase activity and suboptimal levels of vitamin B(12).

Life Sci. (2006)
PMID: 16297937

PS I test B12 on most of my patients and find it very low on most. Since B12 is made by flora in the gut and so many food animals (especially chickens) are given antibiotics as growth stimulators, meat really is not a source of B12 anymore.

And now we see that the antibiotics given to food animals puts children at a disadvantage in clearing pesticides.

My conclusions:

Autism is caused by industrial agriculture!

The same pattern leads to heart disease and dementia in adults.


Industrial agriculture kills.